EP300 promotes ferroptosis via HSPA5 acetylation in pancreatic cancer

Abstract Ferroptosis is a form of regulated cell death characterized by oxidative injury-induced lipid peroxidation. However, the detailed protein post-translational modification regulatory mechanism of ferroptosis remains largely unknown. Here, we report that E1A binding protein P300 (EP300) acetyl...

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Bibliographic Details
Main Authors: Yuan Wang, Yang Liu, Cong Wang, Rui Kang, Daolin Tang, Jiao Liu
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42136-8