Evaluation of the humoral and mucosal immune response of a multiepitope vaccine against COVID-19 in pigs

Evaluation of the humoral and mucosal immune response of a multiepitope vaccine against COVID-19 in pigs

IntroductionThis study evaluated the immune response to a multiepitope recombinant chimeric protein (CHIVAX) containing B- and T-cell epitopes of the SARS-CoV-2 spike’s receptor binding domain (RBD) in a translational porcine model for pre-clinical studies.MethodsWe generated a multiepitope recombin...

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Bibliographic Details
Main Authors: Juan Mosqueda, Diego Josimar Hernández-Silva, Marco Antonio Vega-López, Lineth J. Vega-Rojas, Rolando Beltrán, Andrés Velasco-Elizondo, María del Carmen Ramírez-Estudillo, Mario Fragoso-Saavedra, Chyntia Pérez-Almeida, Jesús Hernández, Edgar A. Melgoza-González, Diana Hinojosa-Trujillo, Miguel Ángel Mercado-Uriostegui, Alma Susana Mejía-López, Carlos Rivera-Ballesteros, Teresa García-Gasca
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Immunology
Subjects:
COVID-19
recombinant protein
multiepitopic vaccine
SARS-CoV-2
humoral response
mucosal immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276950/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1276950/full

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