The Interplay between α-Synuclein and Microglia in α-Synucleinopathies

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies

Synucleinopathies are a set of devastating neurodegenerative diseases that share a pathologic accumulation of the protein α-synuclein (α-syn). This accumulation causes neuronal death resulting in irreversible dementia, deteriorating motor symptoms, and devastating cognitive decline. While the etiolo...

Full description

Bibliographic Details
Main Authors:	Jacob S. Deyell, Manjari Sriparna, Mingyao Ying, Xiaobo Mao
Format:	Article
Language:	English
Published:	MDPI AG 2023-01-01
Series:	International Journal of Molecular Sciences
Subjects:	dementia cognition microglia α-synuclein neuroinflammation synucleinopathies
Online Access:	https://www.mdpi.com/1422-0067/24/3/2477

Similar Items

Possible Alterations in β-Synuclein, the Non-Amyloidogenic Homologue of α-Synuclein, during Progression of Sporadic α-Synucleinopathies
by: Makoto Hashimoto, et al.
Published: (2012-09-01)

Lymphocyte Activation Gene 3 (Lag3) Contributes to α-Synucleinopathy in α-Synuclein Transgenic Mice
by: Hao Gu, et al.
Published: (2021-03-01)

Pathogenic Impact of α-Synuclein Phosphorylation and Its Kinases in α-Synucleinopathies
by: Ichiro Kawahata, et al.
Published: (2022-06-01)

α-Synuclein conformers reveal link to clinical heterogeneity of α-synucleinopathies
by: Matthias Schmitz, et al.
Published: (2023-03-01)

Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies
by: Chao Peng, et al.
Published: (2018-01-01)

Mechanism of Anti-α-Synuclein Immunotherapy
by: Jun Sung Lee, et al.
Published: (2016-01-01)

Reduced Cytosolic Calcium as an Early Decisive Cellular State in Parkinson’s Disease and Synucleinopathies
by: Cristine Betzer, et al.
Published: (2018-11-01)

Structural and Functional Insights into α-Synuclein Fibril Polymorphism
by: Surabhi Mehra, et al.
Published: (2021-09-01)

α-Synuclein Conformational Plasticity: Physiologic States, Pathologic Strains, and Biotechnological Applications
by: Amanda Li, et al.
Published: (2022-07-01)

Biochemical Fractionation of Human α-Synuclein in a <i>Drosophila</i> Model of Synucleinopathies
by: Khondamir Imomnazarov, et al.
Published: (2024-03-01)

Pathological α-synuclein detected by real-time quaking-induced conversion in synucleinopathies
by: Juan Huang, et al.
Published: (2024-03-01)

Immunoregulation of microglial polarization: an unrecognized physiological function of α-synuclein
by: Na Li, et al.
Published: (2020-09-01)

Monitoring α-synuclein aggregation
by: Juan Estaun-Panzano, et al.
Published: (2023-01-01)

Chronic Caffeine Treatment Protects Against α-Synucleinopathy by Reestablishing Autophagy Activity in the Mouse Striatum
by: Yanan Luan, et al.
Published: (2018-05-01)

α-Synuclein Strains: Does Amyloid Conformation Explain the Heterogeneity of Synucleinopathies?
by: Simon Oliver Hoppe, et al.
Published: (2021-06-01)

T cell infiltration and upregulation of MHCII in microglia leads to accelerated neuronal loss in an α-synuclein rat model of Parkinson’s disease
by: Meena S. Subbarayan, et al.
Published: (2020-08-01)

From Synaptic Protein to Prion: The Long and Controversial Journey of α-Synuclein
by: Antonio Heras-Garvin, et al.
Published: (2020-09-01)

Quiescent Elongation of α-Synuclein Pre-form Fibrils Under Different Solution Conditions
by: Hengxu Mao, et al.
Published: (2022-05-01)

A Protein Aggregation Inhibitor, Leuco-Methylthioninium Bis(Hydromethanesulfonate), Decreases α-Synuclein Inclusions in a Transgenic Mouse Model of Synucleinopathy
by: Karima Schwab, et al.
Published: (2018-01-01)

Lipids as Trans-Acting Effectors for α-Synuclein in the Pathogenesis of Parkinson’s Disease
by: Kensuke Ikenaka, et al.
Published: (2019-07-01)

Tau oligomers mediate α-synuclein toxicity and can be targeted by immunotherapy
by: Julia E. Gerson, et al.
Published: (2018-03-01)

RT-QuIC Using C-Terminally Truncated α-Synuclein Forms Detects Differences in Seeding Propensity of Different Brain Regions from Synucleinopathies
by: Ilaria Poggiolini, et al.
Published: (2021-05-01)

Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy
by: Natalia Siwecka, et al.
Published: (2023-07-01)

Histone Deacetylase 6 and the Disease Mechanisms of α-Synucleinopathies
by: Miguel Lemos, et al.
Published: (2020-09-01)

The Concept of α-Synuclein Strains and How Different Conformations May Explain Distinct Neurodegenerative Disorders
by: Katja Malfertheiner, et al.
Published: (2021-10-01)

Neurons and Glia Interplay in α-Synucleinopathies
by: Panagiota Mavroeidi, et al.
Published: (2021-05-01)

Overlaps and divergences between tauopathies and synucleinopathies: a duet of neurodegeneration
by: Wen Li, et al.
Published: (2024-03-01)

Icariin Inhibits Overexpression and Aggregation of α-Synuclein in A53T α-Synuclein Transgenic Mice by Regulating Parkin and PLK2
by: Denglei Ma, et al.
Published: (2023-11-01)

Role of α- and β-Synucleins in the Axonal Pathology of Parkinson’s Disease and Related Synucleinopathies
by: Akio Sekigawa, et al.
Published: (2015-05-01)

Kaempferol Has Potent Protective and Antifibrillogenic Effects for α-Synuclein Neurotoxicity In Vitro
by: Masatoshi Inden, et al.
Published: (2021-10-01)

Leukotriene Signaling as a Target in α-Synucleinopathies
by: Katharina Strempfl, et al.
Published: (2022-02-01)

Misfolded α-synuclein causes hyperactive respiration without functional deficit in live neuroblastoma cells
by: Cathryn L. Ugalde, et al.
Published: (2020-01-01)

Revisiting Alpha-Synuclein Pathways to Inflammation
by: Patrícia Lyra, et al.
Published: (2023-04-01)

α-Synuclein at the Presynaptic Axon Terminal as a Double-Edged Sword
by: Li Yang Tan, et al.
Published: (2022-03-01)

CD36‐Binding Amphiphilic Nanoparticles for Attenuation of α‐Synuclein‐Induced Microglial Activation
by: Nanxia Zhao, et al.
Published: (2022-06-01)

Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models
by: Michiyo Iba, et al.
Published: (2020-03-01)

The interplay between α-Synuclein and NLRP3 inflammasome in Parkinson's disease
by: Qianhui Huang, et al.
Published: (2023-12-01)

Transcriptome analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils
by: Isabella Russo, et al.
Published: (2019-09-01)

Phytochemicals as Regulators of Genes Involved in Synucleinopathies
by: Andrei Surguchov, et al.
Published: (2021-04-01)

Autonomic Dysfunction in α-Synucleinopathies
by: José Javier Mendoza-Velásquez, et al.
Published: (2019-04-01)