Cancer Cells Expressing Oncogenic Rat Sarcoma Show Drug-Addiction Toward Epidermal Growth Factor Receptor Antibodies Mediated by Sustained MAPK Signaling

Cancer Cells Expressing Oncogenic Rat Sarcoma Show Drug-Addiction Toward Epidermal Growth Factor Receptor Antibodies Mediated by Sustained MAPK Signaling

Epidermal growth factor receptor (EGFR) antibodies may have detrimental effects in patients with metastatic colorectal cancer expressing oncogenic Rat sarcoma (RAS). Since a significant number of patients acquire RAS-mediated resistance during EGFR-directed treatment, understanding the molecular mec...

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Bibliographic Details
Main Authors: Joseph Tintelnot, Sina Metz, Marie Trentmann, Anna Oberle, Lisa von Wenserski, Christoph Schultheiß, Friederike Braig, Malte Kriegs, Boris Fehse, Kristoffer Riecken, Carsten Bokemeyer, Alexander Stein, Mascha Binder
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Oncology
Subjects:
EGFR antibodies
colorectal cancer
oncogenic RAS
MAPK signaling
acquired resistance
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01559/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01559/full

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