O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4

O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4

BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and increasing neuronal stress. Therefore, investigating...

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Bibliographic Details
Main Authors: Ibtihal M. Alghusen, Marisa S. Carman, Heather Wilkins, Sophiya John Ephrame, Amy Qiang, Wagner B. Dias, Halyna Fedosyuk, Aspin R. Denson, Russell H. Swerdlow, Chad Slawson
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
O-GlcNAc
mitochondrial stress
integrated stress response
activating transcription factor 4 (ATF4)
Alzheimer’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1326127/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1326127/full

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