O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4

O-GlcNAc regulates the mitochondrial integrated stress response by regulating ATF4

BackgroundAccumulation of mitochondrial dysfunctional is a hallmark of age-related neurodegeneration including Alzheimer’s disease (AD). Impairment of mitochondrial quality control mechanisms leading to the accumulation of damaged mitochondria and increasing neuronal stress. Therefore, investigating...

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Bibliographic Details
Main Authors:	Ibtihal M. Alghusen, Marisa S. Carman, Heather Wilkins, Sophiya John Ephrame, Amy Qiang, Wagner B. Dias, Halyna Fedosyuk, Aspin R. Denson, Russell H. Swerdlow, Chad Slawson
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-12-01
Series:	Frontiers in Aging Neuroscience
Subjects:	O-GlcNAc mitochondrial stress integrated stress response activating transcription factor 4 (ATF4) Alzheimer’s disease
Online Access:	https://www.frontiersin.org/articles/10.3389/fnagi.2023.1326127/full

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