Cortical tau deposition follows patterns of entorhinal functional connectivity in aging
Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer’s disease (AD) is hypothesized to involve amyloid-β (Aβ) facilitated tau spread through neural connections. We contrasted functional connectivity (FC) of alEC...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2019-09-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/49132 |
| _version_ | 1811201320302936064 |
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| author | Jenna N Adams Anne Maass Theresa M Harrison Suzanne L Baker William J Jagust |
| author_facet | Jenna N Adams Anne Maass Theresa M Harrison Suzanne L Baker William J Jagust |
| author_sort | Jenna N Adams |
| collection | DOAJ |
| description | Tau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer’s disease (AD) is hypothesized to involve amyloid-β (Aβ) facilitated tau spread through neural connections. We contrasted functional connectivity (FC) of alEC and posteromedial EC (pmEC), subregions of EC that differ in functional specialization and cortical connectivity, with the hypothesis that alEC-connected cortex would show greater tau deposition than pmEC-connected cortex. We used resting state fMRI to measure FC, and PET to measure tau and Aβ in cognitively normal older adults. Tau preferentially deposited in alEC-connected cortex compared to pmEC-connected or non-connected cortex, and stronger connectivity was associated with increased tau deposition. FC-tau relationships were present regardless of Aβ, although strengthened with Aβ. These results provide an explanation for the anatomic specificity of neocortical tau deposition in the aging brain and reveal relationships between normal aging and the evolution of AD. |
| first_indexed | 2024-04-12T02:18:55Z |
| format | Article |
| id | doaj.art-64bd885a74f94b44b48dc38832189b46 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T02:18:55Z |
| publishDate | 2019-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-64bd885a74f94b44b48dc38832189b462022-12-22T03:52:10ZengeLife Sciences Publications LtdeLife2050-084X2019-09-01810.7554/eLife.49132Cortical tau deposition follows patterns of entorhinal functional connectivity in agingJenna N Adams0https://orcid.org/0000-0002-6702-3851Anne Maass1Theresa M Harrison2https://orcid.org/0000-0002-2036-3496Suzanne L Baker3https://orcid.org/0000-0003-0209-3127William J Jagust4https://orcid.org/0000-0002-4458-113XHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, United StatesHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, United States; German Center for Neurodegenerative Disease, Magdeburg, GermanyHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, United StatesLawrence Berkeley National Laboratory, Berkeley, United StatesHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, United States; Lawrence Berkeley National Laboratory, Berkeley, United StatesTau pathology first appears in the transentorhinal and anterolateral entorhinal cortex (alEC) in the aging brain. The transition to Alzheimer’s disease (AD) is hypothesized to involve amyloid-β (Aβ) facilitated tau spread through neural connections. We contrasted functional connectivity (FC) of alEC and posteromedial EC (pmEC), subregions of EC that differ in functional specialization and cortical connectivity, with the hypothesis that alEC-connected cortex would show greater tau deposition than pmEC-connected cortex. We used resting state fMRI to measure FC, and PET to measure tau and Aβ in cognitively normal older adults. Tau preferentially deposited in alEC-connected cortex compared to pmEC-connected or non-connected cortex, and stronger connectivity was associated with increased tau deposition. FC-tau relationships were present regardless of Aβ, although strengthened with Aβ. These results provide an explanation for the anatomic specificity of neocortical tau deposition in the aging brain and reveal relationships between normal aging and the evolution of AD.https://elifesciences.org/articles/49132tauPETfunctional connectivityagingentorhinal cortexAlzheimer's disease |
| spellingShingle | Jenna N Adams Anne Maass Theresa M Harrison Suzanne L Baker William J Jagust Cortical tau deposition follows patterns of entorhinal functional connectivity in aging eLife tau PET functional connectivity aging entorhinal cortex Alzheimer's disease |
| title | Cortical tau deposition follows patterns of entorhinal functional connectivity in aging |
| title_full | Cortical tau deposition follows patterns of entorhinal functional connectivity in aging |
| title_fullStr | Cortical tau deposition follows patterns of entorhinal functional connectivity in aging |
| title_full_unstemmed | Cortical tau deposition follows patterns of entorhinal functional connectivity in aging |
| title_short | Cortical tau deposition follows patterns of entorhinal functional connectivity in aging |
| title_sort | cortical tau deposition follows patterns of entorhinal functional connectivity in aging |
| topic | tau PET functional connectivity aging entorhinal cortex Alzheimer's disease |
| url | https://elifesciences.org/articles/49132 |
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