Suppressing the Substance P-NK1R Signalling Protects Mice against Sepsis-Associated Acute Inflammatory Injury and Ferroptosis in the Liver and Lungs

Suppressing the Substance P-NK1R Signalling Protects Mice against Sepsis-Associated Acute Inflammatory Injury and Ferroptosis in the Liver and Lungs

Substance P (SP), encoded by the <i>TAC1/Tac1</i> gene, acts as a significant mediator in dysregulated systemic inflammatory response and associated organ injury in sepsis by activating the neurokinin-1 receptor (NK1R). This study investigated the impact of SP-NK1R signaling on ferroptos...

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Bibliographic Details
Main Authors: Zhixing Zhu, Stephen Chambers, Madhav Bhatia
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Antioxidants
Subjects:
substance P
neurokinin-1 receptor
ferroptosis
liver injury
lung injury
sepsis
Online Access:https://www.mdpi.com/2076-3921/13/3/300

Internet

https://www.mdpi.com/2076-3921/13/3/300

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