α-Mangostin suppresses ethanol-induced gastric ulceration by regulating the Nrf2/HO-1 and NF-κB/NLRP3/caspase-1 signaling pathways and gut microbiota

α-Mangostin suppresses ethanol-induced gastric ulceration by regulating the Nrf2/HO-1 and NF-κB/NLRP3/caspase-1 signaling pathways and gut microbiota

α-Mangostin is a natural xanthone derivative isolated from Camellia atrophy (CA), commonly known as Lichuan black tea (LBT). The present study investigated the ameliorating effect and mechanism of α-mangostin on alcoholic gastric ulcers (GU) in rats. In vivo, α-mangostin relieved pathological sympto...

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Bibliographic Details
Main Authors: Suqin Yang, Gang Liu, Xiankun Xia, Dali Gan, Shijian Xiang, Meixian Xiang
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Heliyon
Subjects:
Gastric ulceration
α-Mangostin
Anti-oxidative stress
Anti-inflammation
Autophagy
Nrf2/HO-1 pathway and NF-κB/NLRP3/Caspase-1 pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024003700

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http://www.sciencedirect.com/science/article/pii/S2405844024003700

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