Studies on Biological and Molecular Effects of Small-Molecule Kinase Inhibitors on Human Glioblastoma Cells and Organotypic Brain Slices

Studies on Biological and Molecular Effects of Small-Molecule Kinase Inhibitors on Human Glioblastoma Cells and Organotypic Brain Slices

Glioblastoma is the most common and aggressive primary brain tumor. Multiple genetic and epigenetic alterations in several major signaling pathways—including the phosphoinositide 3-kinases (PI3K)/AKT/mTOR and the Raf/MEK/ERK pathway—could be found. We therefore aimed to investigate the biological an...

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Bibliographic Details
Main Authors: Julia Hörnschemeyer, Timo Kirschstein, Gesine Reichart, Christin Sasse, Jakob Venus, Anne Einsle, Katrin Porath, Michael Linnebacher, Rüdiger Köhling, Falko Lange
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Life
Subjects:
glioblastoma
low-passage glioblastoma cell lines
ipatasertib
MK-2206
dactolisib
trametinib
Online Access:https://www.mdpi.com/2075-1729/12/8/1258

Internet

https://www.mdpi.com/2075-1729/12/8/1258

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