Protein over-expression in Escherichia coli triggers adaptation analogous to antimicrobial resistance

Protein over-expression in Escherichia coli triggers adaptation analogous to antimicrobial resistance

Abstract Background The E. coli pET system is the most widely used protein over-expression system worldwide. It relies on the assumption that all cells produce target protein and it is generally believed that integral membrane protein (IMP) over-expression is more toxic than their soluble counterpar...

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Bibliographic Details
Main Authors: Jack James, Benjamin Yarnall, Andy Koranteng, Jane Gibson, Tahmina Rahman, Declan A. Doyle
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Microbial Cell Factories
Subjects:
Escherichia coli
Antimicrobial resistance
BL21(DE3)
Protein over-expression
Online Access:https://doi.org/10.1186/s12934-020-01462-6

Internet

https://doi.org/10.1186/s12934-020-01462-6

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