S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

S327 phosphorylation of the presynaptic protein SEPTIN5 increases in the early stages of neurofibrillary pathology and alters the functionality of SEPTIN5

Alzheimer's disease (AD) is the most common form of dementia, which is neuropathologically characterized by extracellular senile plaques containing amyloid-β and intracellular neurofibrillary tangles composed of hyperphosphorylated tau protein. Previous studies have suggested a role for septin...

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Bibliographic Details
Main Authors: Catarina B. Ferreira, Mikael Marttinen, Joana E. Coelho, Kaisa M.A. Paldanius, Mari Takalo, Petra Mäkinen, Luukas Leppänen, Catarina Miranda-Lourenço, João Fonseca-Gomes, Sara R. Tanqueiro, Sandra H. Vaz, Rita F. Belo, Ana Maria Sebastião, Ville Leinonen, Hilkka Soininen, Ian Pike, Annakaisa Haapasalo, Luísa V. Lopes, Alexandre de Mendonça, Maria José Diógenes, Mikko Hiltunen
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Neurobiology of Disease
Subjects:
Aβ
Alzheimer's disease
APP processing
Autophagy
Post-translational modifications
SEPTIN5
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121003521

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http://www.sciencedirect.com/science/article/pii/S0969996121003521

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