Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9

Alterations in glycosylation in tumours facilitate tumour progression. Here, the authors show that pancreatic ductal adenocarcinomas present increased sialylation, which stimulates the polarisation of monocytes via Siglec receptors, resulting in the generation of immune suppressive tumour associated...

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Bibliographic Details
Main Authors: Ernesto Rodriguez, Kelly Boelaars, Kari Brown, R. J. Eveline Li, Laura Kruijssen, Sven C. M. Bruijns, Thomas van Ee, Sjoerd T. T. Schetters, Matheus H. W. Crommentuijn, Joost C. van der Horst, Nicole C. T. van Grieken, Sandra J. van Vliet, Geert Kazemier, Elisa Giovannetti, Juan J. Garcia-Vallejo, Yvette van Kooyk
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21550-4

Internet

https://doi.org/10.1038/s41467-021-21550-4

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