Interpretation of active-control randomised trials: the case for a new analytical perspective involving averted events
Abstract Active-control trials, where an experimental treatment is compared with an established treatment, are performed when the inclusion of a placebo control group is deemed to be unethical. For time-to-event outcomes, the primary estimand is usually the rate ratio, or the closely-related hazard...
Main Authors: | David T. Dunn, Oliver T. Stirrup, Sheena McCormack, David V. Glidden |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-06-01
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Series: | BMC Medical Research Methodology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12874-023-01970-0 |
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