Monoclonal Antibody Disrupts Biofilm Structure and Restores Antibiotic Susceptibility in an Orthopedic Implant Infection Model

Monoclonal Antibody Disrupts Biofilm Structure and Restores Antibiotic Susceptibility in an Orthopedic Implant Infection Model

Bacterial biofilms on orthopedic implants are resistant to the host immune response and to traditional systemic antibiotics. Novel therapies are needed to improve patient outcomes. TRL1068 is a human monoclonal antibody (mAb) against a biofilm anchoring protein. For assessment of this agent in an or...

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Bibliographic Details
Main Authors: Zachary D. C. Burke, Christopher M. Hart, Benjamin V. Kelley, Zeinab Mamouei, Gideon W. Blumstein, Christopher Hamad, Kellyn Hori, Nicolas Cevallos, Christina Villalpando, Nicole Truong, Amr Turkmani, Micah Ralston, Aaron Kavanaugh, Edgar Tenorio, Lawrence M. Kauvar, Alan Li, Nathanael Prunet, Alexandra I. Stavrakis, Nicholas M. Bernthal
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Antibiotics
Subjects:
biofilm
orthopedic implant infection
<i>S. aureus</i>
spinal implant infection
prosthetic joint infection
monoclonal antibody
Online Access:https://www.mdpi.com/2079-6382/12/10/1490

Internet

https://www.mdpi.com/2079-6382/12/10/1490

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