Gene expression levels and inhibitory effect of 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]Pyrimidin-9(1H)-one (MCL) against AP2-I and BDP1 in malaria experimental models

Gene expression levels and inhibitory effect of 7-[(7-methoxy-4,5-dihydro-1H-benzo[g]indazol-3-yl)carbonyl]-2-phenyl-5,6,7,8-tetrahydropyrazolo[1,5-a]pyrido[4,3-d]Pyrimidin-9(1H)-one (MCL) against AP2-I and BDP1 in malaria experimental models

Resistance to antimalarial drugs leads a global recurrence of malaria, posing a significant challenge to malaria control. This study aimed to assess gene expression and resistance profiles in clinical isolates, and validate the inhibitory effect of MCL compound against PbAP2-I and PbBDP1 genes in vi...

Full description

Bibliographic Details
Main Authors: David O Oladejo, Dorathy O Anzaku, Collins O Mamudu, Temitope Elugbadebo, Titilope M Dokunmu, Ezekiel F Adebiyi, Emeka EJ Iweala
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Scientific African
Subjects:
Plasmodium falciparum
Plasmodium berghei
Antimalarial drug resistance
Gene expression
MCL
Inhibitory activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2468227623004647

Internet

http://www.sciencedirect.com/science/article/pii/S2468227623004647

Similar Items