Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine

Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine

Abstract Ketamine shows rapid antidepressant effects peaking 24 h after administration. The antidepressant effects may occur through changes in glutamatergic metabolite levels and resting-state functional connectivity (rsFC) within the default mode network (DMN). A multistage drug effect of ketamine...

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Bibliographic Details
Main Authors: Lena Vera Danyeli, Zümrüt Duygu Sen, Lejla Colic, Lisa Kurzweil, Sabrina Gensberger-Reigl, Tamar Macharadze, Florian Götting, Alexander Refisch, Thomas Liebe, Tara Chand, Moritz Kretzschmar, Gerd Wagner, Nils Opel, Fabrice Jollant, Oliver Speck, Matthias H. J. Munk, Meng Li, Martin Walter
Format: Article
Language:English
Published: Nature Publishing Group 2023-02-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02346-0

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https://doi.org/10.1038/s41398-023-02346-0

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