A cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models

A cisplatin conjugate with tumor cell specificity exhibits antitumor effects in renal cancer models

Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and is notorious for its resistance to both chemotherapy and small-molecule inhibitor targeted therapies. Subcellular targeted cancer therapy may thwart the resistance to produce a substantial effect...

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Bibliographic Details
Main Authors: Stefan Mrdenovic, Yanping Wang, Lijuan Yin, Gina Chia-Yi Chu, Yan Ou, Michael S. Lewis, Marija Heffer, Edwin M. Posadas, Haiyen E. Zhau, Leland W. K. Chung, Mouad Edderkaoui, Stephen J. Pandol, Ruoxiang Wang, Yi Zhang
Format: Article
Language:English
Published: BMC 2023-06-01
Series:BMC Cancer
Subjects:
Kidney cancer
Heptamethine carbocyanine dye
Cisplatin
Conjugate
Cell death
Online Access:https://doi.org/10.1186/s12885-023-10878-3

Internet

https://doi.org/10.1186/s12885-023-10878-3

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