Determinants and Mechanisms of the Low Fusogenicity and High Dependence on Endosomal Entry of Omicron Subvariants

Determinants and Mechanisms of the Low Fusogenicity and High Dependence on Endosomal Entry of Omicron Subvariants

ABSTRACT The rapid spread and strong immune evasion of the SARS-CoV-2 Omicron subvariants has raised serious concerns for the global COVID-19 pandemic. These new variants exhibit generally reduced fusogenicity and increased endosomal entry pathway utilization compared to the ancestral D614G variant,...

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Bibliographic Details
Main Authors: Panke Qu, John P. Evans, Chaitanya Kurhade, Cong Zeng, Yi-Min Zheng, Kai Xu, Pei-Yong Shi, Xuping Xie, Shan-Lu Liu
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
Omicron subvariants
furin cleavage
fusogenicity
endosomal entry
H655Y
Online Access:https://journals.asm.org/doi/10.1128/mbio.03176-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03176-22

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