Fasudil Loaded PLGA Microspheres as Potential Intravitreal Depot Formulation for Glaucoma Therapy

Fasudil Loaded PLGA Microspheres as Potential Intravitreal Depot Formulation for Glaucoma Therapy

Rho-associated protein kinase (ROCK) inhibitors allow for causative glaucoma therapy. Unfortunately, topically applied ROCK inhibitors suffer from high incidence of hyperemia and low intraocular bioavailability. Therefore, we propose the use of poly (lactide-co-glycolide) (PLGA) microspheres as a de...

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Bibliographic Details
Main Authors: Raphael Mietzner, Christian Kade, Franziska Froemel, Diana Pauly, W. Daniel Stamer, Andreas Ohlmann, Joachim Wegener, Rudolf Fuchshofer, Miriam Breunig
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Pharmaceutics
Subjects:
drug delivery
glaucoma
ROCK inhibitor
fasudil
PLGA microspheres
intravitreal injection
Online Access:https://www.mdpi.com/1999-4923/12/8/706

Internet

https://www.mdpi.com/1999-4923/12/8/706

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