Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma

Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma

Background: Uveal melanoma (UM), a rare cancer of the eye, is characterized by initiating mutations in the genes G-protein subunit alpha Q (<i>GNAQ</i>), G-protein subunit alpha 11 (<i>GNA11</i>), cysteinyl leukotriene receptor 2 (<i>CYSLTR2</i>), and phospholipas...

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Bibliographic Details
Main Authors: Francesca Piaggio, Veronica Tozzo, Cinzia Bernardi, Michela Croce, Roberto Puzone, Silvia Viaggi, Serena Patrone, Annalisa Barla, Domenico Coviello, Martine J. Jager, Pieter A. van der Velden, Michael Zeschnigk, Davide Cangelosi, Alessandra Eva, Ulrich Pfeffer, Adriana Amaro
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
driver mutation
gene set enrichment
tumor evolution
mutation signature
Online Access:https://www.mdpi.com/2072-6694/11/11/1688

Internet

https://www.mdpi.com/2072-6694/11/11/1688

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