Unexpected BrdU inhibition on astrocyte-to-neuron conversion

Unexpected BrdU inhibition on astrocyte-to-neuron conversion

5-Bromo-2′-deoxyuridine (BrdU) is a halogenated pyrimidine that can be incorporated into newly synthesized DNA during the S phase of the cell cycle. BrdU is widely used in fate-mapping studies of embryonic and adult neurogenesis to identify newborn neurons, however side effects on neural stem cells...

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Bibliographic Details
Main Authors: Tao Wang, Jian-Cheng Liao, Xu Wang, Qing-Song Wang, Kai-Ying Wan, Yi-Yi Yang, Qing He, Jia-Xuan Zhang, Gong Chen, Wen Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2022-01-01
Series:Neural Regeneration Research
Subjects:
5-bromo-2′-deoxyuridine; neurod1; astrocyte-to-neuron conversion; reprogramming; neural regeneration; reactive astrocytes; neurons; lineage tracing; fate mapping; neural stem cell
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=7;spage=1526;epage=1534;aulast=Wang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2022;volume=17;issue=7;spage=1526;epage=1534;aulast=Wang

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