Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors

Therapeutic potential of targeting Nrf2 by panobinostat in pituitary neuroendocrine tumors

Abstract We aimed to identify the druggable cell-intrinsic vulnerabilities and target-based drug therapies for PitNETs using the high-throughput drug screening (HTS) and genomic sequencing methods. We examined 9 patient-derived PitNET primary cells in HTS. Based on the screening results, the potenti...

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Bibliographic Details
Main Authors: Yijun Cheng, Yuting Dai, Hao Tang, Xingyu Lu, Jing Xie, Wanqun Xie, Qianqian Zhang, Yanting Liu, Shaojian Lin, Hong Yao, Hanbing Shang, Kun Yang, Hongyi Liu, Xuefeng Wu, Jianming Zhang, Xun Zhang, Li Xue, Zhe Bao Wu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:Acta Neuropathologica Communications
Subjects:
PitNETs
High-throughput screening
HDACIs
Panobinostat
Nrf2
Online Access:https://doi.org/10.1186/s40478-024-01775-2

Internet

https://doi.org/10.1186/s40478-024-01775-2

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