Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits

Traumatic Brain Injury in Aged Mice Induces Chronic Microglia Activation, Synapse Loss, and Complement-Dependent Memory Deficits

Traumatic brain injury (TBI) is of particular concern for the aging community since there is both increased incidence of TBI and decreased functional recovery in this population. In addition, TBI is the strongest environmental risk factor for development of Alzheimer’s disease and other de...

Full description

Bibliographic Details
Main Authors: Karen Krukowski, Austin Chou, Xi Feng, Brice Tiret, Maria-Serena Paladini, Lara-Kirstie Riparip, Myriam M. Chaumeil, Cynthia Lemere, Susanna Rosi
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
traumatic brain injury
complement
C1q
microglia
synapse
Online Access:https://www.mdpi.com/1422-0067/19/12/3753

Internet

https://www.mdpi.com/1422-0067/19/12/3753

Similar Items