CRF-R1 Antagonist Treatment Exacerbates Circadian Corticosterone Secretion under Chronic Stress, but Preserves HPA Feedback Sensitivity

CRF-R1 Antagonist Treatment Exacerbates Circadian Corticosterone Secretion under Chronic Stress, but Preserves HPA Feedback Sensitivity

Despite promising initial reports, corticotropin-releasing factor receptor type-1 (CRF-R1) antagonists have mostly failed to display efficacy in clinical trials for anxiety or depression. Rather than broad-spectrum antidepressant/anxiolytic-like drugs, they may represent an ‘antistress’ solution for...

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Bibliographic Details
Main Authors: Yadira Ibarguen-Vargas, Samuel Leman, Rupert Palme, Catherine Belzung, Alexandre Surget
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceutics
Subjects:
CRF
CRF receptor type 1 antagonist
HPA axis
glucocorticoids
chronic stress
antidepressant
Online Access:https://www.mdpi.com/1999-4923/13/12/2114

Internet

https://www.mdpi.com/1999-4923/13/12/2114

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