Sodium-Glucose Co-Transporter 2 Inhibitors Correct Metabolic Maladaptation of Proximal Tubular Epithelial Cells in High-Glucose Conditions

Sodium-Glucose Co-Transporter 2 Inhibitors Correct Metabolic Maladaptation of Proximal Tubular Epithelial Cells in High-Glucose Conditions

Glucose filtered in the glomerulus is actively reabsorbed by sodium-glucose co-transporter 2 (SGLT2) in proximal tubular epithelial cells (PTEC) and passively returned to the blood via glucose transporter 2 (GLUT2). Healthy PTEC rely primarily on fatty acid beta-oxidation (FAO) for energy. In phase...

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Bibliographic Details
Main Authors: Kohsuke Shirakawa, Motoaki Sano
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
osteopontin
proximal tubular epithelial cells
SGLT2
GLUT2
2-deoxy-D-glucose
myo-inositol oxygenase
Online Access:https://www.mdpi.com/1422-0067/21/20/7676

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https://www.mdpi.com/1422-0067/21/20/7676

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