Design, Synthesis, In-silico ADME prediction Molecular docking and Antitubercular screening of Bromo-pyridyl tethered 3-chloro 2-azetidinone Derivatives

Design, Synthesis, In-silico ADME prediction Molecular docking and Antitubercular screening of Bromo-pyridyl tethered 3-chloro 2-azetidinone Derivatives

In the present investigation, we have designed and synthesized a new series of β-lactam derivatives 9a-j containing bromo-pyridyl moiety via [2+2]-ketenimine cycloaddition, initially the intermediate hydrazone derivatives 7a-j were synthesized via conventional and microwave methods. All the new synt...

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Bibliographic Details
Main Authors: Rakesh V. Kusurkar, Rahul H. Rayani, Deepa R. Parmar, Manoj N Bhoi, Vishwanath H Zunjar, Jigar Y. Soni
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Results in Chemistry
Subjects:
Antimycobacterial
2-azetidinone
Molecular docking
ADMET prediction
Microwave
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715622000765

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http://www.sciencedirect.com/science/article/pii/S2211715622000765

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