Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

Mechanisms of antibiotic action shape the fitness landscapes of resistance mutations

Antibiotic-resistant pathogens are a major public health threat. A deeper understanding of how an antibiotic’s mechanism of action influences the emergence of resistance would aid in the design of new drugs and help to preserve the effectiveness of existing ones. To this end, we developed a model th...

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Bibliographic Details
Main Authors: Colin Hemez, Fabrizio Clarelli, Adam C. Palmer, Christina Bleis, Sören Abel, Leonid Chindelevitch, Theodore Cohen, Pia Abel zur Wiesch
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Antibiotic resistance
Clinical microbiology
Fitness landscape
Global health
Multiscale modeling
Pharmacodynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022003634

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http://www.sciencedirect.com/science/article/pii/S2001037022003634

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