UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

UDP-4-Keto-6-Deoxyglucose, a Transient Antifungal Metabolite, Weakens the Fungal Cell Wall Partly by Inhibition of UDP-Galactopyranose Mutase

ABSTRACT Can accumulation of a normally transient metabolite affect fungal biology? UDP-4-keto-6-deoxyglucose (UDP-KDG) represents an intermediate stage in conversion of UDP-glucose to UDP-rhamnose. Normally, UDP-KDG is not detected in living cells, because it is quickly converted to UDP-rhamnose by...

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Bibliographic Details
Main Authors: Liang Ma, Omar Salas, Kyle Bowler, Maor Bar-Peled, Amir Sharon
Format: Article
Language:English
Published: American Society for Microbiology 2017-12-01
Series:mBio
Subjects:
Botrytis cinerea
UDP-4-keto-6-deoxyglucose
UDP-galactopyranose mutase
fungal cell wall
fungal nucleotide sugar metabolism
galactofuranose
Online Access:https://journals.asm.org/doi/10.1128/mBio.01559-17

Internet

https://journals.asm.org/doi/10.1128/mBio.01559-17

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