Essential Role of Histidine for Rapid Copper(II)-Mediated Disassembly of Neurokinin B Amyloid

Neurokinin B is a tachykinin peptide involved in a diverse range of neuronal functions. It rapidly forms an amyloid, which is considered physiologically important for efficient packing into dense core secretory vesicles within hypothalamic neurons. Disassembly of the amyloid is thought to require th...

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Bibliographic Details
Main Authors: Bhawantha M. Jayawardena, Lorraine Peacey, Roland Gamsjaeger, Christopher E. Jones
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
Online Access:https://www.mdpi.com/2218-273X/12/11/1585