Successful treatment with baloxavir marboxil of a patient with peramivir-resistant influenza A/H3N2 with a dual E119D/R292K substitution after allogeneic hematopoietic cell transplantation: a case report

Successful treatment with baloxavir marboxil of a patient with peramivir-resistant influenza A/H3N2 with a dual E119D/R292K substitution after allogeneic hematopoietic cell transplantation: a case report

Abstract Background Extended use of oseltamivir in an immunocompromised host could reportedly induce neuraminidase gene mutation possibly leading to oseltamivir-resistant influenza A/H3N2 virus. To our knowledge, no report is available on the clinical course of a severely immunocompromised patient w...

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Bibliographic Details
Main Authors: Naonori Harada, Wataru Shibata, Hideo Koh, Emi Takashita, Seiichiro Fujisaki, Hiroshi Okamura, Satoru Nanno, Koichi Yamada, Hirohisa Nakamae, Masayuki Hino, Hiroshi Kakeya
Format: Article
Language:English
Published: BMC 2020-07-01
Series:BMC Infectious Diseases
Subjects:
Allogeneic hematopoietic cell transplantation
Baloxavir marboxil
Neuraminidase mutation
Dual E119D/R292K substitution
Peramivir resistance
Immunocompromised host
Online Access:http://link.springer.com/article/10.1186/s12879-020-05205-1

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http://link.springer.com/article/10.1186/s12879-020-05205-1

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