Downregulating Mitochondrial DNA Polymerase γ in the Muscle Stimulated Autophagy, Apoptosis, and Muscle Aging-Related Phenotypes in <i>Drosophila</i> Adults

Downregulating Mitochondrial DNA Polymerase γ in the Muscle Stimulated Autophagy, Apoptosis, and Muscle Aging-Related Phenotypes in <i>Drosophila</i> Adults

Reactive oxygen species, generated as by-products of mitochondrial electron transport, can induce damage to mitochondrial DNA (mtDNA) and proteins. Here, we investigated whether the moderate accumulation of mtDNA damage in adult muscles resulted in accelerated aging-related phenotypes in <i>Dr...

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Bibliographic Details
Main Authors: Mika Ozaki, Tuan Dat Le, Yoshihiro H. Inoue
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biomolecules
Subjects:
mitochondria
DNA polymeraseγ
<i>Drosophila</i>
muscle aging
autophagy
Online Access:https://www.mdpi.com/2218-273X/12/8/1105

Internet

https://www.mdpi.com/2218-273X/12/8/1105

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