Evaluation of neuroprotective agents acting via the BDNF–TrkB pathway using AI‐enabled predictions of ligand–receptor interactions

Evaluation of neuroprotective agents acting via the BDNF–TrkB pathway using AI‐enabled predictions of ligand–receptor interactions

Abstract Glaucoma is the leading cause of irreversible blindness globally and is associated with retinal ganglion cell (RGC) death. Brain‐derived neurotrophic factor (BDNF) is a potent neurotrophin that promotes neuronal survival via its receptor, tropomyosin receptor kinase B (TrkB) encoded by NTRK...

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Bibliographic Details
Main Authors: Jing Zhu, Jun Zou, Fei Li, Yuanxu Gao, Lijun Wang, Yi Sun, Jie Zhu, Xiaomeng Zhang, Kanmin Xue, Gen Li, Nga M. Cheng, Juan Guo, Xiulan Zhang, Kang Zhang
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:MedComm – Future Medicine
Subjects:
7,8‐dihydroxyflavone
deep learning
ganglion cell
glaucoma
Online Access:https://doi.org/10.1002/mef2.15

Internet

https://doi.org/10.1002/mef2.15

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