Effect of Folate-deficient Diet and 5-Fluorouracil Treatment In the zn VlVO Model of Mice L1210 Leukemia
The present study investigated the effect of reduced folic acid content in the organism, due to deficient diet, on the survival time of mice with L1210 leukemia, treated with fluorouracil. One of the mechanisms of the cytotoxic effect of fluorouracil is the inhibition of thymidylate synthase by bind...
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| Format: | Article |
| Language: | English |
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De Gruyter
1994-08-01
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| Series: | Pteridines |
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| Online Access: | https://doi.org/10.1515/pteridines.1994.5.3.107 |