Toxicity Profile of eBAT, a Bispecific Ligand-Targeted Toxin Directed to EGFR and uPAR, in Mice and a Clinical Dog Model

Toxicity Profile of eBAT, a Bispecific Ligand-Targeted Toxin Directed to EGFR and uPAR, in Mice and a Clinical Dog Model

EGFR-targeted therapies are efficacious, but toxicity is common and can be severe. Urokinase type plasminogen activator receptor (uPAR)-targeted drugs are only emerging, so neither their efficacy nor toxicity is fully established. Recombinant eBAT was created by combining cytokines EGF and uPA on th...

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Bibliographic Details
Main Authors: Rose H. Dicovitsky, Jill T. Schappa, Ashley J. Schulte, Haeree P. Lang, Ellen Kuerbitz, Sarah Roberts, Taylor A. DePauw, Mitzi Lewellen, Amber L. Winter, Kathy Stuebner, Michelle Buettner, Kelly Reid, Kelly Bergsrud, Sara Pracht, Andrea Chehadeh, Caitlin Feiock, M. Gerard O’Sullivan, Tim Carlson, Alexandra R. Armstrong, Danielle Meritet, Michael S. Henson, Brenda J. Weigel, Jaime F. Modiano, Antonella Borgatti, Daniel A. Vallera
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Toxins
Subjects:
targeted therapy
sarcoma
pharmacology
toxicity
immunotoxin
Online Access:https://www.mdpi.com/2072-6651/16/9/376

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https://www.mdpi.com/2072-6651/16/9/376

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