Isoflurane mediated neuropathological and cognitive impairments in the triple transgenic Alzheimer's mouse model are associated with hippocampal synaptic deficits in an age-dependent manner.
Many in vivo studies suggest that inhalational anesthetics can accelerate or prevent the progression of neuropathology and cognitive impairments in Alzheimer Disease (AD), but the synaptic mechanisms mediating these ambiguous effects are unclear. Here, we show that repeated exposures of neonatal and...
| Main Authors: | , , , , |
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| Format: | Article |
| Jezik: | English |
| Izdano: |
Public Library of Science (PLoS)
2019-01-01
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| Serija: | PLoS ONE |
| Online dostop: | https://doi.org/10.1371/journal.pone.0223509 |