Oxidized-LDL Deteriorated the Renal Residual Function and Parenchyma in CKD Rat through Upregulating Epithelial Mesenchymal Transition and Extracellular Matrix-Mediated Tubulointerstitial Fibrosis—Pharmacomodulation of Rosuvastatin

Oxidized-LDL Deteriorated the Renal Residual Function and Parenchyma in CKD Rat through Upregulating Epithelial Mesenchymal Transition and Extracellular Matrix-Mediated Tubulointerstitial Fibrosis—Pharmacomodulation of Rosuvastatin

This study tested the hypothesis that intrarenal arterial transfusion of oxidized low-density lipoprotein (ox-LDL) jeopardized the residual renal function and kidney architecture in rat chronic kidney disease ((CKD), i.e., induced by 5/6 nephrectomy) that was reversed by rosuvastatin. Cell culture w...

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Bibliographic Details
Main Authors: Pei-Hsun Sung, Ben-Chung Cheng, Tsuen-Wei Hsu, John Y Chiang, Hsin-Ju Chiang, Yi-Ling Chen, Chih-Chao Yang, Hon-Kan Yip
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Antioxidants
Subjects:
chronic kidney disease
oxidized low-density lipoprotein
epithelial mesenchymal transition
oxidative stress
Online Access:https://www.mdpi.com/2076-3921/11/12/2465

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https://www.mdpi.com/2076-3921/11/12/2465

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