Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase

Current understanding of nucleoside analogs inhibiting the SARS-CoV-2 RNA-dependent RNA polymerase

Since the outbreak of the COVID-19 pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA-dependent RNA polymerase (RdRp) has become a main target for antiviral therapeutics due to its essential role in viral replication and transcription. Thus, nucleoside analogs structurally re...

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Bibliographic Details
Main Authors: Tiantian Xu, Lu Zhang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
SARS-CoV-2
RNA-dependent RNA polymerase
Nucleoside analog
Cryo-EM structure
Computational simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023003124

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http://www.sciencedirect.com/science/article/pii/S2001037023003124

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