The Citrus Flavonoid Hesperetin Has an Inadequate Anti-Arrhythmic Profile in the ΔKPQ Na<sub>V</sub>1.5 Mutant of the Long QT Type 3 Syndrome
Type 3 long QT syndromes (LQT3) are associated with arrhythmogenic gain-of-function mutations in the cardiac voltage-gated Na<sup>+</sup> channel (hNa<sub>V</sub>1.5). The citrus flavanone hesperetin (HSP) was previously suggested as a template molecule to develop new anti-ar...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/10/6/952 |