Capturing Structural Variants of Herpes Simplex Virus Genome in Full Length by Oxford Nanopore Sequencing

Capturing Structural Variants of Herpes Simplex Virus Genome in Full Length by Oxford Nanopore Sequencing

ABSTRACT Genome sequencing and assembly of viral genomes within the Herpesviridae family, particularly herpes simplex virus (HSV), have been challenging due to the large size (~154 Kb), high GC content (68%), and nucleotide variations arising during replication. Oxford Nanopore Technology (ONT) has...

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Bibliographic Details
Main Authors: Rajagopalan Saranathan, Emmanuel Asare, Lawrence Leung, Anna Paula de Oliveira, Katherine E. Kaugars, Claire V. Mulholland, Regy Lukose, Michael Berney, William R. Jacobs
Format: Article
Language:English
Published: American Society for Microbiology 2022-10-01
Series:Microbiology Spectrum
Subjects:
genome isomers
Oxford Nanopore sequencing
herpes simplex virus
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02285-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.02285-22

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