Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery

Development of a new hazard scoring system in primary neuronal cell cultures for drug-induced acute neuronal toxicity identification in early drug discovery

We investigated drug-induced acute neuronal electrophysiological changes using Micro-Electrode arrays (MEA) to rat primary neuronal cell cultures. Data based on 6-key MEA parameters were analyzed for plate-to-plate vehicle variability, effects of positive and negative controls, as well as data from...

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Bibliographic Details
Main Authors: Mohamed Kreir, Dea Putri, Fetene Tekle, Francesca Pibiri, Constantin d’Ydewalle, Karel Van Ammel, Helena Geys, Ard Teisman, David J. Gallacher, Hua Rong Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Pharmacology
Subjects:
neuronal cells
micro-electrode array (MEA)
neuronal toxicity
seizures
adverse effect (AE)
hazard score system
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1308547/full

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https://www.frontiersin.org/articles/10.3389/fphar.2024.1308547/full

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