Whole-Exome Sequencing Reveals Recurrent but Heterogeneous Mutational Profiles in Sporadic WHO Grade 1 Meningiomas

Whole-Exome Sequencing Reveals Recurrent but Heterogeneous Mutational Profiles in Sporadic WHO Grade 1 Meningiomas

Human WHO grade 1 meningiomas are generally considered benign tumors; despite this, they account for ≈50% of all recurrent meningiomas. Currently, limited data exist about the mutational profiles of grade 1 meningiomas and patient outcome. We investigated the genetic variants present in 32 WHO grade...

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Bibliographic Details
Main Authors: María González-Tablas, Carlos Prieto, Daniel Arandia, María Jara-Acevedo, Álvaro Otero, Daniel Pascual, Laura Ruíz, Iván Álvarez-Twose, Andrés Celestino García-Montero, Alberto Orfao, María Dolores Tabernero
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
mutational profiles
whole exome sequencing (WES)
NF2
PTEN
cytogenetics
WHO grade 1 meningioma
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.740782/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.740782/full

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