Differential metabolic alterations in IDH1 mutant vs. wildtype glioma cells promote epileptogenesis through distinctive mechanisms

Differential metabolic alterations in IDH1 mutant vs. wildtype glioma cells promote epileptogenesis through distinctive mechanisms

Glioma-related epilepsy (GRE) is a hallmark clinical presentation of gliomas with significant impacts on patient quality of life. The current standard of care for seizure management is comprised of anti-seizure medications (ASMs) and surgical resection. Seizures in glioma patients are often drug-res...

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Bibliographic Details
Main Authors: Darrian McAfee, Mitchell Moyer, Jaden Queen, Armin Mortazavi, Ujwal Boddeti, Muzna Bachani, Kareem Zaghloul, Alexander Ksendzovsky
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Cellular Neuroscience
Subjects:
tumor-related epilepsy
brain
glioma
seizure development
tumoral metabolism
peritumoral excitability
Online Access:https://www.frontiersin.org/articles/10.3389/fncel.2023.1288918/full

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https://www.frontiersin.org/articles/10.3389/fncel.2023.1288918/full

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