Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain

Chromatin and transcriptomic profiling uncover dysregulation of the Tip60 HAT/HDAC2 epigenomic landscape in the neurodegenerative brain

Disruption of histone acetylation-mediated gene control is a critical step in Alzheimer’s Disease (AD), yet chromatin analysis of antagonistic histone acetyltransferases (HATs) and histone deacetylases (HDACs) causing these alterations remains uncharacterized. We report the first Tip60 HAT versus HD...

Full description

Bibliographic Details
Main Authors: Mariah Beaver, Bhanu Chandra Karisetty, Haolin Zhang, Akanksha Bhatnagar, Ellen Armour, Visha Parmar, Reshma Brown, Merry Xiang, Felice Elefant
Format: Article
Language:English
Published: Taylor & Francis Group 2022-07-01
Series:Epigenetics
Subjects:
amyloid precursor protein
sequencing
histone acetylation
alzheimer’s disease
kat5
Online Access:http://dx.doi.org/10.1080/15592294.2021.1959742

Internet

http://dx.doi.org/10.1080/15592294.2021.1959742

Similar Items