The Challenge of Producing Ubiquitinated Proteins for Structural Studies

The Challenge of Producing Ubiquitinated Proteins for Structural Studies

Protein ubiquitination is an important post-translational modification involved in several essential signalling pathways. It has different effects on the target protein substrate, i.e., it can trigger the degradation of the protein in the proteasome, change the interactions of the modified protein w...

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Bibliographic Details
Main Authors: Serena Faggiano, Annalisa Pastore
Format: Article
Language:English
Published: MDPI AG 2014-06-01
Series:Cells
Subjects:
ubiquitin
post-translational modification
mono-ubiquitination
isopeptide bond
native chemical ligation
non-enzymatic ubiquitination
enzymatic ubiquitination
in vitro ubiquitination
X-ray crystallography
nuclear magnetic resonance spectroscopy
Online Access:http://www.mdpi.com/2073-4409/3/2/639

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http://www.mdpi.com/2073-4409/3/2/639

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