Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus

Lurasidone Sub-Chronically Activates Serotonergic Transmission via Desensitization of 5-HT1A and 5-HT7 Receptors in Dorsal Raphe Nucleus

Lurasidone is an atypical mood-stabilizing antipsychotic agent with unique receptor-binding profile, including 5-HT7 receptor (5-HT7R) antagonism. Effects of 5-HT7R antagonism on transmitter systems of schizophrenia and mood disorders, however, have not been well clarified. Thus, this study examined...

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Bibliographic Details
Main Authors: Motohiro Okada, Kouji Fukuyama, Ruri Okubo, Takashi Shiroyama, Yuto Ueda
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Pharmaceuticals
Subjects:
lurasidone
serotonin
gaba
microdialysis
schizophrenia
mood disorder
Online Access:https://www.mdpi.com/1424-8247/12/4/149

Internet

https://www.mdpi.com/1424-8247/12/4/149

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