Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development

Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development

T cells are generated from hematopoietic stem cells through a highly organized developmental process, in which stage-specific molecular events drive maturation towards αβ and γδ T cells. Although many of the mechanisms that control αβ- and γδ-lineage differentiation are shared between human and mous...

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Bibliographic Details
Main Authors: Juliette Roels, Jolien Van Hulle, Marieke Lavaert, Anna Kuchmiy, Steven Strubbe, Tom Putteman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Lena Boehme, Tom Taghon
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Immunology
Subjects:
E proteins
ID proteins
T cell development
human
thymocytes
gene regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.960918/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.960918/full

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