PEMT Mediates Hepatitis C Virus-Induced Steatosis, Explains Genotype-Specific Phenotypes and Supports Virus Replication

PEMT Mediates Hepatitis C Virus-Induced Steatosis, Explains Genotype-Specific Phenotypes and Supports Virus Replication

The hepatitis C virus (HCV) relies on cellular lipid pathways for virus replication and also induces liver steatosis, but the mechanisms involved are not clear. We performed a quantitative lipidomics analysis of virus-infected cells by combining high-performance thin-layer chromatography (HPTLC) and...

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Bibliographic Details
Main Authors: Mosleh Abomughaid, Enoch S. E. Tay, Russell Pickford, Chandra Malladi, Scott A. Read, Jens R. Coorssen, Brian S. Gloss, Jacob George, Mark W. Douglas
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
hepatitis C virus
lipidomics
PEMT
phosphatidyl choline
lipid metabolism
steatosis
Online Access:https://www.mdpi.com/1422-0067/24/10/8781

Internet

https://www.mdpi.com/1422-0067/24/10/8781

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