The Extracts of <i>Polygonum cuspidatum</i> Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease

The Extracts of <i>Polygonum cuspidatum</i> Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease

COVID-19, resulting from infection by the SARS-CoV-2 virus, caused a contagious pandemic. Even with the current vaccines, there is still an urgent need to develop effective pharmacological treatments against this deadly disease. Here, we show that the water and ethanol extracts of the root and rhizo...

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Bibliographic Details
Main Authors: Shengying Lin, Xiaoyang Wang, Roy Wai-Lun Tang, Hung Chun Lee, Ho Hin Chan, Sheyne S. A. Choi, Tina Ting-Xia Dong, Ka Wing Leung, Sarah E. Webb, Andrew L. Miller, Karl Wah-Keung Tsim
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
SARS-CoV-2
omicron variant
traditional Chinese medicine
pseudovirus entry
Polygoni Cuspidati Rhizoma et Radix
zebrafish larvae
Online Access:https://www.mdpi.com/1420-3049/27/12/3806

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https://www.mdpi.com/1420-3049/27/12/3806

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