Jatrophone: a cytotoxic macrocylic diterpene targeting PI3K/AKT/NF-κB pathway, inducing apoptosis and autophagy in resistant breast cancer cells

Jatrophone: a cytotoxic macrocylic diterpene targeting PI3K/AKT/NF-κB pathway, inducing apoptosis and autophagy in resistant breast cancer cells

Abstract Background Breast cancer is a prevalent malignant tumor that affects women worldwide. The primary challenge in treating breast cancer is combating drug resistance, which contributes to relapse and metastasis. Jatrophone is a unique macrocyclic jatrophane diterpene found in various Jatropha...

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Bibliographic Details
Main Authors: Khawlah Shari, Rania A. El Gedaily, Rasha M. Allam, Khaled M. Meselhy, Amal E. Khaleel, Essam Abdel-Sattar
Format: Article
Language:English
Published: BMC 2023-08-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Jatrophone
Jatropha spinosa
Doxorubicin-resistant breast Cancer
Early apoptosis
PI3K/AKT/NF-κB
Autophagy
Online Access:https://doi.org/10.1186/s12906-023-04113-6

Internet

https://doi.org/10.1186/s12906-023-04113-6

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